Drug Metabolism


Are your medications poisoning you? Are you taking medication to reduce side effects from another prescription? Are you afraid of all of those box warnings? Did you know there is a genetic test to relieve those concerns?
A shift in healthcare has begun. Welcome to Premier DNA, your personalized, precision medicine solution. Our simple test can identify the most common drug side effects for cardiovascular, diabetes, mental heath, chronic pain,and anti-inflammatory medications.
With a simple swab of your cheeks, Premier DNA test can guide you and your Dr to select the right medications for you at the right time, and right dose.

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Why Genomic Testing?

Pharmacogenetics — the study of drug interaction with an individual’s genetic makeup — can provide another piece of information to aid the physician when selecting a patient’s medication and initial dosage. This helps eliminate adverse drug reactions or lack of therapeutic effect under standard therapy conditions. For example, there is a large degree of inter-individual variability in the pharmacodynamic response to clopidogrel (Plavix) and patients with the inability to metabolize the drug are at greater risk for adverse cardiovascular events. Nonresponsiveness to clopidogrel is widely reported. Approximately 25% of patients taking clopidogrel experience a sub-therapeutic antiplatelet response that is associated with an increased risk of recurrent ischemic events.

When drugs metabolized by the Cytochrome P450 (CYP) enzymes are administered, variant genotypes are associated with increased potential for Adverse Drug Reactions (ADR), therapeutic failure and risk of drug interactions. A prospective study of US hospitals estimated that 106,000 Americans die annually from ADR.2

Your report will outline the metabolizer status of your patient. This will allow you to select and dose medication based on each patient’s unique ability to metabolize a drug. There are four types of drug metabolizers:

  • Poor: They have very low levels of enzyme activity and process certain medications at a lower than
    normal rate.
  • Intermediate: They dispose of drugs more slowly, between an extensive and poor rate of metabolism.
  • Normal (Extensive): They are considered normal and usually have the expected response to a drug.
  • Ultra-rapid: They have high levels of enzyme activity and process drugs at a higher-than-normal rate.
    These patients may not achieve therapeutic plasma levels at the normal dose.